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2nd Symposium of the Genetics and Evolution of the Skeleton Research Initiative (Bone section courtesy of Mr. Ron Oldfield,

Development, Diseases and Evolution of Mineralized Tissues

December 15, 2009
Toland Hall, UC Hall Building, 533 Parnassus
University of California San Francisco

10:00 am to 5:30 pm
Reception to follow on the Nursing Mezzanine

Through GESRI, biologists from all disciplines concerned with the vertebrate skeleton come together to discover how our evolutionary history has shaped the genetic mechanisms that form and heal our skeletons.

Program Schedule


Opening remarks
Ophir Klein (Director, Craniofacial and Mesenchymal Biology Program, UCSF
Leslea Hlusko (Human Evolution Research Center, UC Berkeley)


Rich Schneider (Department of Orthopaedic Surgery, UCSF)
"Mesenchymally-mediated mechanisms of bone mineralization and growth"


Celine Colnot (Department of Orthopaedic Surgery, UCSF)
"Cellular and molecular bases of skeletal regeneration"


Nancy E. Lane (Director, Aging Center, Medicine and Rheumatology, UCD Medical Center)
"Wnt signalling and osteoarthritis of the hip: The bone and joint connection"


Clare Yellowley (UC Davis School of Veterinary Medicine)
"Repairing mineralized tissue: The fracture healing environment"


lunch break


Tamara Alliston (Department of Orthopaedic Surgery, UCSF)
"Hard-headed and big-boned: TGF-beta regulation of bone matrix quality"


Daniel Bikle (Veterans Affairs Medical Center and UCSF)
"Role of IGF-I in skeletal development, growth, and responsiveness to anabolic stimuli"


Pamela Den Besten (Department of Orofacial Sciences, School of Dentistry, UCSF)
"Tooth tissue bioengineering: Clues from mice and men"


Mark Goodwin (Assistant Director, UC Museum of Paleontology)
"Elemental analysis, composition and 'soft tissue' preservation in dinosaur bioapatite"


Kerstin Seidel (Department of Orofacial Sciences, School of Dentistry, UCSF)
"SHH is a master regulator of stem cell-driven continuous growth of the mouse incisor"


coffee break



Debbie Guatelli-Steinberg (Dept. of Anthropology, Ohio State University)
"Evolution and variation of tooth mineralization in humans and primates"


David Kingsley (Dept. of Developmental Biology, Stanford University School of Medicine)
"Stickleback fish as a model for understanding bone mineralization and its evolutionary history"


reception on the Nursing Mezzanine

Major funding generously provided by the UC Berkeley Dean of Biological Sciences, the UCSF Department of Orthopaedic Surgery, and the Human Evolution Research Center (UC Berkeley).

Additional funding and support provided by UCSF's Department of Orofacial Sciences and Department of Orthopaedic Surgery, UC Berkeley's Department of Integrative Biology, and:

University of California Museum of Paleontology Orthopaedic Trauma Institute, San Francisco General Hospital Craniofacial and Mesenchymal Biology Human Evolution Research Center